Description
SPON1, also known as F-Spondin, is a member of a sub-group of TSR(thrombospondin) molecules. It is a cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurities in vitro. This protein may contribute to the growth and guidance of axons. SPON1 is also major factor for vascular smooth muscle cell. It shows highest expression in lung and lowest expression in pancreas, skeletal muscle and ovary. This protein binds to the central extracellular of APP and inhibits beta-secretase cleavage of APP. Recombinant human SPON1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques